Unravel
the
Complexity

of Systemic sclerosis

SYSTEMIC SCLEROSIS IS A RARE, DEBILITATING & COMPLEX AUTOIMMUNE DISEASE

Systemic sclerosis (SSc) affects up to 75,000 Americans per year and is one of the most fatal autoimmune disorders.1-3

SSc can be limited or diffuse based on the extent of skin and internal organ involvement. Diffuse SSc can have deleterious effects on the lungs, heart, and kidneys.4-6

Not an actual patient.

Risk icon

DIFFUSE SSc POSES THE
GREATEST RISK

Prognosis varies with organ involvement, but is generally poor.7-9

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EARLY INTERVENTION MAY IMPROVE OUTCOMES

Organ involvement tends to occur within 3 years of disease onset.3,6,9-12

SSc SNAPSHOT

SSc IS AMONG THE MOST FATAL AUTOIMMUNE DISEASES

1 in 4 patients

1 in 4 PATIENTS

with diffuse SSc die within
8 years of diagnosis7

4x mortality risk

4X MORTALITY RISK

in SSc patients compared to
healthy counterparts7

11-26 years lost

11-22 YEARS LOST

from life expectancy on average
compared to healthy counterparts7

INFLAMMATION & FIBROSIS ARE THE HALLMARKS OF SYSTEMIC SCLEROSIS

SSc is a disease of dysregulated immune response. It's fueled by a complex interplay of underlying mechanisms of disease that drive persistent systemic inflammation. This leads to vasculopathy, fibrosis of the skin, tissue ischemia, hypoxia and ultimately organ cell damage.1,13,14

Immune activation icon

IMMUNE ACTIVATION & INFLAMMATION

  • Drives antibody production and inflammation, causing vasculopathy that leads to blood vessel narrowing9,13,15
Fibroblast icon

FIBROBLAST ACTIVATION & FIBROSIS

  • Causes accumulation of protein deposits in the skin and internal organs that lead to organ damage9,14,16
SSc SNAPSHOT

THE VICIOUS CYCLE OF INFLAMMATION & FIBROSIS IN SYSTEMIC SCLEROSIS13-16

Cycle of inflammation and fibrosis in systemic sclerosis

SEE THE TOTALITY OF
SYSTEMIC SCLEROSIS

Patients with SSc face a physical and psychological burden that can range from distressing to debilitating or even fatal.9,17

SSc SNAPSHOT

THE TOTAL IMPACT OF SYSTEMIC SCLEROSIS ON PATIENTS

9 in 10 patients

9 in 10
PATIENTS

with diffuse SSc report
some level of disability18

2 out of 3 patients

2 out of 3
PATIENTS

become unable to work and show symptoms of depression19-23

SYSTEMIC SCLEROSIS IS MORE THAN SKIN DEEP

As you explore the potential range of symptoms and comorbidities, the total impact of SSc becomes all the more apparent.

Systemic
Complications1,3,11,17,24-27,29,30

Skin

Painful ulcerations, functional impairment, hypo/hyperpigmentation, contractures, disfiguration

Inflammatory & Vascular

Raynaud's phenomenon, infection, telangiectasia, arthralgia, synovitis

Psychological & Cognitive

Mood disorders (e.g. depression), anxiety/panic, sexual dysfunction, clouding of consciousness, visual-spatial issues, reduced problem-solving abilities, syncope

General Physical

Pain, itching, fatigue, difficulty sleeping

Human body

Organ
Complications1,3,11,25,28

Pulmonary

Fibrosis, interstitial lung disease, pulmonary arterial hypertension, reduced lung diffusing capacity, shortness of breath, chest pain, dry cough

Cardiac

Pericardial effusion, conduction abnormalities, hypertension, coronary artery disease, arrhythmia, pericarditis, heart failure

Renal

Scleroderma renal crisis (progressive impairment, hyperreninemia, accelerated phase hypertension, and acute renal failure with vascular lesions), chronic kidney disease, proteinuria, albuminuria

Gastrointestinal

Reflux, difficulty swallowing or eating, reduced esophageal motility, malabsorption, weight loss, bleeding, pseudo-obstruction, incontinence, early satiety, bloating, diarrhea, esophageal ulcers